dcsimg

Birnaviridae

provided by wikipedia EN

Birnaviridae Virus classification Group: Group III (dsRNA) Family: Birnaviridae Genera Birnavirus VP2 protein PDB 2df7 EBI.jpg
crystal structure of infectious bursal disease virus vp2 subviral particle
IdentifiersSymbol Birna_VP2Pfam PF01766Pfam clan CL0055InterPro IPR002662 Available protein structures:Pfam structuresPDB RCSB PDB; PDBe; PDBjPDBsum structure summary Birnavirus VP3 proteinIdentifiersSymbol Birna_VP3Pfam PF01767InterPro IPR002663 Available protein structures:Pfam structuresPDB RCSB PDB; PDBe; PDBjPDBsum structure summary Birnavirus VP4 proteinIdentifiersSymbol Birna_VP4Pfam PF01768InterPro IPR002664MEROPS S50 Available protein structures:Pfam structuresPDB RCSB PDB; PDBe; PDBjPDBsum structure summary Birnavirus VP5 proteinIdentifiersSymbol Birna_VP5Pfam PF03042InterPro IPR004284 Available protein structures:Pfam structuresPDB RCSB PDB; PDBe; PDBjPDBsum structure summary

Birnaviridae is a family of viruses. Salmonid fish, young sexually immature chickens, and insects serve as natural hosts. There are currently six species in this family, divided among 4 genera. Diseases associated with this family include: IPNV: infectious pancreatic necrosis in salmonid fish, causes significant losses to the aquaculture industry. chronic infection in adult, and acute viral disease in young salmonid fish.[1][2]

Birnaviridae proteins

The Birnaviridae genome encodes several proteins:

Birnaviridae RNA-directed RNA polymerase (VP1), which lacks the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RNA-directed RNA polymerases.[3]

The large RNA segment, segment A, of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [4] that is processed into the major structural proteins of the virion: VP2, VP3 (a minor structural component of the virus), and into the putative protease VP4.[4] VP4 protein is involved in generating VP2 and VP3.[4] recombinant VP3 is more immunogenic than recombinant VP2.[5]

Infectious pancreatic necrosis virus (IPNV), a birnavirus, is an important pathogen in fish farms. Analyses of viral proteins showed that VP2 is the major structural and immunogenic polypeptide of the virus.[6][7] All neutralizing monoclonal antibodies are specific to VP2 and bind to continuous or discontinuous epitopes. The variable domain of VP2 and the 20 adjacent amino acids of the conserved C-terminal are probably the most important in inducing an immune response for the protection of animals.[6]

Non structural protein VP5 is found in RNA segment A. The function of this small viral protein is unknown. It is believed to be involved in influencing apoptosis, but studies are not completely concurring. The protein can not be found in the virion.

Structure

Viruses in Birnaviridae are non-enveloped, with icosahedral and Single-shelled geometries, and T=13 symmetry. The diameter is around 70 nm. Genomes are linear and segmented, around 15.2.3-3kb in length. The genome codes for 5 to 6 proteins.[1]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation Avibirnavirus Icosahedral T=13 Non-enveloped Linear Segmented Aquabirnavirus Icosahedral T=13 Non-enveloped Linear Segmented Blosnavirus Icosahedral T=13 Non-enveloped Linear Segmented Entomobirnavirus Icosahedral T=13 Non-enveloped Linear Segmented

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by penetration into the host cell. Replication follows the double-stranded RNA virus replication model. Double-stranded rna virus transcription is the method of transcription. Salmonid fish, young sexually immature chickens, and insects serve as the natural host. Transmission routes are contact.[1]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission Avibirnavirus Birds None Cell receptor endocytosis Budding Cytoplasm Cytoplasm Contact Aquabirnavirus Salmonid fish None Cell receptor endocytosis Budding Cytoplasm Cytoplasm Contact Blosnavirus Blotched snakehead fish None Unknown Budding Cytoplasm Cytoplasm Unknown Entomobirnavirus Insects: diptera None Cell receptor endocytosis Budding Cytoplasm Cytoplasm Unknown

Taxonomy

Group: dsRNA

[2]

References

  1. ^ a b c "Viral Zone". ExPASy. Retrieved 12 June 2015..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""'"'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
  2. ^ a b ICTV. "Virus Taxonomy: 2014 Release". Retrieved 12 June 2015.
  3. ^ Shwed PS, Dobos P, Cameron LA, Vakharia VN, Duncan R (May 2002). "Birnavirus VP1 proteins form a distinct subgroup of RNA-dependent RNA polymerases lacking a GDD motif". Virology. 296 (2): 241–250. doi:10.1006/viro.2001.1334. PMID 12069523.
  4. ^ a b c Jagadish MN, Staton VJ, Hudson PJ, Azad AA (March 1988). "Birnavirus precursor polyprotein is processed in Escherichia coli by its own virus-encoded polypeptide". J. Virol. 62 (3): 1084–7. PMC 253673. PMID 2828658.
  5. ^ Moon CH, Do JW, Cha SJ, Bang JD, Park MA, Yoo DJ, Lee JM, Kim HG, Chung DK, Park JW (October 2004). "Comparison of the immunogenicity of recombinant VP2 and VP3 of infectious pancreatic necrosis virus and marine birnavirus". Arch. Virol. 149 (10): 2059–68. PMID 15669113.
  6. ^ a b Heppell J, Tarrab E, Lecomte J, Berthiaume L, Arella M (December 1995). "Strain variability and localization of important epitopes on the major structural protein (VP2) of infectious pancreatic necrosis virus". Virology. 214 (1): 40–9. doi:10.1006/viro.1995.9956. PMID 8525637.
  7. ^ Nobiron I, Galloux M, Henry C, Torhy C, Boudinot P, Lejal N, Da Costa B, Delmas B (February 2008). "Genome and polypeptides characterization of Tellina virus 1 reveals a fifth genetic cluster in the Birnaviridae family". Virology. 371 (2): 350–61. doi:10.1016/j.virol.2007.09.022. PMID 17976679.

license
cc-by-sa-3.0
copyright
Wikipedia authors and editors
original
visit source
partner site
wikipedia EN

Birnaviridae: Brief Summary

provided by wikipedia EN

Birnaviridae is a family of viruses. Salmonid fish, young sexually immature chickens, and insects serve as natural hosts. There are currently six species in this family, divided among 4 genera. Diseases associated with this family include: IPNV: infectious pancreatic necrosis in salmonid fish, causes significant losses to the aquaculture industry. chronic infection in adult, and acute viral disease in young salmonid fish.

license
cc-by-sa-3.0
copyright
Wikipedia authors and editors
original
visit source
partner site
wikipedia EN