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Madagascar Periwinkle

Catharanthus roseus (L.) G. Don

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An extract from the root is used for the cure of blood cancer. Flowers are also used as a remedy for diabetes.
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Flora of Pakistan Vol. 0: 18 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Comments

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Cultivated for medicine. Decoction of all parts is used in the treatment of malaria, skin diseases, Hodgkin's disease, diarrhea, hypertension, and diabetes.
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Flora of China Vol. 16: 157 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Description

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Perennial subshrub, woody at base, 30-60 cm tall, young branches pubescent. Leaves oblong or oblanceolate, membranous, 2.5-6 x 1.5-3 cm, entire, obtuse or mucronate, base obtuse or cuneate, glabrous or sparingly hairy specially on nerves beneath, shining green above, paler below, lateral nerves obscure; petiole short, 3-10 mm long, with many glands at the axil. Inflorescence of axillary 1-4 flowered cymes, Flowers pink or white, pedicel 1-3 mm long. Calyx tube short, lobes linear acute, 5-7 mm long, hairy. Corolla tube 20-25 mm long, sparsely pubescent above, throat densely hairy within below the stamens, lobes oblong-rounded, or obovate, 15-25 mm long spreading Disc scales higher than ovary, c. 2-3 mm long. Ovary pubescent; style c. 2.5 cm long; stigma pentagonal. Follicles 2, slender, cylindric, striated. 15-25 mm long.
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
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Flora of Pakistan Vol. 0: 18 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of Pakistan @ eFloras.org
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S. I. Ali & M. Qaiser
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Description

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Subshrubs or perennial herbs to 1 m tall, erect or decumbent. Young stems puberulent. Leaves obovate or elliptic, 2.5-9 X 1-3.5 cm, herbaceous, apex minutely apiculate; lateral veins 7-11 pairs. Corolla red to pink or white and then mostly with a pink or less often yellow eye; tube 2.5-3 cm, pilose inside, throat villous; lobes broadly obovate, 1.2-2 cm. Follicles 2-3.8 cm X ca. 3 mm. Fl. spring-autumn. 2n = 16.
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Flora of China Vol. 16: 157 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Distribution

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Native of tropical America; widely naturalised elsewhere in the tropics.
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Annotated Checklist of the Flowering Plants of Nepal Vol. 0 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Annotated Checklist of the Flowering Plants of Nepal @ eFloras.org
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Distribution

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Distribution: A native of Madagascar, widely cultivated and naturalized in tropics and subtropics of both hemisphere.
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Flora of Pakistan Vol. 0: 18 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of Pakistan @ eFloras.org
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Elevation Range

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150-1500 m
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Annotated Checklist of the Flowering Plants of Nepal Vol. 0 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Annotated Checklist of the Flowering Plants of Nepal @ eFloras.org
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Flower/Fruit

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Fl. Per.: Throughout the year.
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Flora of Pakistan Vol. 0: 18 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of Pakistan @ eFloras.org
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Habitat & Distribution

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Fujian, Guizhou, Hunan, Jiangsu, Jiangxi, Sichuan, Yunnan, Zhejiang [native to Madagascar, cultivated or naturalized in all tropical countries]
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Flora of China Vol. 16: 157 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of China @ eFloras.org
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Wu Zhengyi, Peter H. Raven & Hong Deyuan
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Synonym

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Vinca rosea Linnaeus, Syst. Nat. ed. 10. 944. 1759; Ammocallis rosea (Linnaeus) Small; Catharanthus roseus var. albus G. Don; Lochnera rosea (Linnaeus) Reichenbach ex Endlicher; L. rosea var. alba (G. Don) Hubbard; L. rosea var. flava Tsiang; Pervinca rosea (Linnaeus) Moench; V. rosea var. alba (G. Don) Sweet.
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
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Flora of China Vol. 16: 157 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of China @ eFloras.org
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Wu Zhengyi, Peter H. Raven & Hong Deyuan
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Derivation of specific name

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roseus: rose, rosy
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Mark Hyde, Bart Wursten and Petra Ballings
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Hyde, M.A., Wursten, B.T. and Ballings, P. (2002-2014). Catharanthus roseus (L.) G. Don Flora of Zimbabwe website. Accessed 28 August 2014 at http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=145040
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Bart Wursten
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Description

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Erect or decumbent suffrutex, to 1 m, usually with white latex. Stems green, often suffused with purple or red. Leaves decussate, petiolate; lamina variable, elliptic, obovate or narrowly obovate; apex mucronate. Flowers 4-5 cm, showy, white or pink, with a purple, red, pale yellow or white centre. Follicle 1.2-3.8 × 0.2-0.3 cm, dehiscent on the adaxial side. Seeds 1-2 mm, numerous, grooved on one side.
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Mark Hyde, Bart Wursten and Petra Ballings
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Hyde, M.A., Wursten, B.T. and Ballings, P. (2002-2014). Catharanthus roseus (L.) G. Don Flora of Zimbabwe website. Accessed 28 August 2014 at http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=145040
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Mark Hyde
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Frequency

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Locally common
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Mark Hyde, Bart Wursten and Petra Ballings
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Hyde, M.A., Wursten, B.T. and Ballings, P. (2002-2014). Catharanthus roseus (L.) G. Don Flora of Zimbabwe website. Accessed 28 August 2014 at http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=145040
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Worldwide distribution

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Native to Madagascar
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Mark Hyde, Bart Wursten and Petra Ballings
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Hyde, M.A., Wursten, B.T. and Ballings, P. (2002-2014). Catharanthus roseus (L.) G. Don Flora of Zimbabwe website. Accessed 28 August 2014 at http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=145040
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Mark Hyde
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Comprehensive Description

provided by Smithsonian Contributions to Botany
Catharanthus roseus (L.) Don

Vinca rosea L., Syst. 10th ed. 2:944. 1759.—Hillebrand, Fl. Haw. Is. 294. 1888.—Butteaud, Fl. Tahiti. 58. 1891.—Drake del Castillo, Ill. Fl. Ins. Pac. 7:234. 1892.—Hemsley, Journ. Linn. Soc. Bot. 30:185. 1894.—Burkill, Journ. Linn. Soc. Bot. 35:46. 1901.—Cheeseman, Trans. Linn. Soc. 6:287. 1903.—Rock, Indig. Trees Haw. 407. 1913.—Wilder, Bish. Mus. Bull. 86:89. 1931.—F.B.H. Brown, Bish. Mus. Bull. 130:234. 1935.

Lochnera rosea Reichenbach, Consp. 134. 1828.—Pancher in Cuzent, Iles Soc. Tahiti 235. 1860.—Reinecke, Bot. Jahrb. 25:667. 1898.—Rechinger, Denks. Akad. Wien 85:330. 1910.—Setchell, Univ. Cal. Pub. Bot. 12:201. 1926.—Wilder, Bish. Mus. Bull. 120:40. 1934.—Christophersen, Bish. Mus. Bull. 128:180. 1935.

Catharanthus roseus (L.) Don, Gen. Hist. 4:95. 1838.—Degener, Fl. Haw. 1933.

Vinca alba Butteaud, Fl. Tahiti. 58. 1891 [nomen nudum; non Noronha, 1790 (= Ervatamia divaricata)].

DESCRIPTION.—Herb, 3–8 dm high, puberulent. Leaves opposite. Petioles 3–5 mm long. Blades oblong to obovate, 3.5–5 × 1.5–2.5 cm, cuneate at base, rounded and apiculate at tip, chartaceous. Flowers axillary, paired. Calyx lobes subulate, 2–3 mm long. Corolla salverform, white or rose, often with a white, red, or yellow center; tube 2.5 cm long; lobes obovate, 1.5 × 1.2 cm, rounded, sinistrorse. Follicles 2, 2.5 × 0.5 cm. Seeds oblong, 2 × 1 mm, finely wrinkled.

RANGE.—Society Islands (cultivated): Raiatea: Moore 207, Uturoa, alt. 1 m, 13 October 1926, flower (white) and fruit (BISH, 2 sheets; MIN). Borabora: Grant 5084, Nunue, Vaitape, alt. 1 m, 18 January 1931, flower (white) (BISH, MIN).

First reported by Pancher (in Cuzent) in 1860. According to Butteaud it was introduced by Bishop d'Axieri. Native of Madagascar. Also cultivated in the Marquesas (!). Naturalized in Makatea, Hawaii, Samoa, and Rarotonga.

LOCAL NAMES.—English: Periwinkle, Madagascar periwinkle. French: pervenche. Samoan: pua ula, according to Reinecke (cf. Fagraea berteriana).
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bibliographic citation
Grant, Martin Lawrence, Fosberg, F. Raymond, and Smith, Howard M. 1974. "Partial Flora of the Society Islands: Ericaceae to Apocynaceae." Smithsonian Contributions to Botany. 1-85. https://doi.org/10.5479/si.0081024X.17

Comprehensive Description

provided by Smithsonian Contributions to Botany
Catharanthus roseus (L.) G. Don

Catharanthus roseus (L.) G. Don, Gen. Hist. Dichl. Pl., 4:95, 1838.

Vinca rosea L., Syst., ed. 10, 944, 1759.—F. Brown, Flora, 234, 1935.

Lochnera rosea (L.) Reichenbach, Consp. 134, 1828.

Erect herb, up to 0.5 m tall, leaves thin, oblong, obtuse, flowers showy, rose, white, or white with a red eye.

One of the most ubiquitous tropical plants, reputed to have important medical properties. Said to be originally from Madagascar. All three color forms planted in gardens in the Marquesas and frequently naturalized.

SPECIMENS SEEN.—Marquesas Islands: Herbier S.FJ.M. 170 (P).

Nukuhiva I.: Savatier 735 (P).

Uahuka I.: Vaipae’e village, Decker 1662 (US); Hane Village, 10 m, Decker 1951 (US).

Uapou I.: Hoho’i Valley, everywhere, mauve or white, Lavondès 14 (US); west flank of Hakahetau, only one seen, 50–250 m. Decker 2258 (US).

Hivaoa I.: Weedy roadside near beach at Atuona, 1–2 m, escaped from cultivation, Sachet 1205 (US, P, BISH, UH); Atuona, escaped from cultivation, Decker 399 (US, BISH, UC, P); among rocks of seashore (obviously escaped from cultivation), PES (M & A) 122 (pink), 116 (white, red eye) (both BISH, LeB); PES Ex 116 (BISH); Puamau, house yard, 100–200 ft [30–70 m], Decker 538 (US); dry slopes between Nahoe and Eiaone, 100–300 ft [30–100 m], Decker 617 (BISH, US); Hanamenu, near marsh back of beach, Decker 1330 (US, Fo).

LOCAL NAMES.—Perevai (borrowing from the French, pervenche) (Lavondès 14), tihapai (PES 122). English: Madagascar periwinkle.

Cerbera L.

Cerbera L., Gen. Pl., ed. 5, 98, 1754 [=1753].

Shrubs or small trees, leaves crowded at ends of branches, spirally arranged; cymes terminal, frequently with conspicuous pale green bracts; corollas salverform, throat narrow or somewhat dilated; fruit a pair of ovoid drupes, stones covered with spine-like fibers.

An Indo-Pacific genus, one species extending to Polynesia.
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bibliographic citation
Sachet, Marie-Hélène. 1975. "Flora of the Marquesas, 1: Ericaceae-Convolvulacae." Smithsonian Contributions to Botany. 1-38. https://doi.org/10.5479/si.0081024X.23

Catharanthus roseus

provided by wikipedia EN

 src=
A white C. roseus flower

Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle,[2] is a species of flowering plant in the family Apocynaceae. It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. It was formerly included in the genus Vinca as Vinca rosea.

Synonyms

Two varieties are recognized

  • Catharanthus roseus var. roseus
Synonymy for this variety
Catharanthus roseus var. angustus Steenis ex Bakhuizen f.[3]
Catharanthus roseus var. albus G.Don[4]
Catharanthus roseus var. occellatus G.Don[4]
Catharanthus roseus var. nanus Markgr.[5]
Lochnera rosea f. alba (G.Don) Woodson[6]
Lochnera rosea var. ocellata (G.Don) Woodson
  • Catharanthus roseus var. angustus (Steenis) Bakh. f.[7]
Synonymy for this variety
Catharanthus roseus var. nanus Markgr.[8]
Lochnera rosea var. angusta Steenis[9]

Description

Catharnthus roseus is an evergreen subshrub or herbaceous plant growing 1 m (39 in) tall. The leaves are oval to oblong, 2.5–9 cm (1.0–3.5 in) long and 1–3.5 cm (0.4–1.4 in) broad, glossy green, hairless, with a pale midrib and a short petiole 1–1.8 cm (0.4–0.7 in) long; they are arranged in opposite pairs. The flowers are white to dark pink with a darker red centre, with a basal tube 2.5–3 cm (1.0–1.2 in) long and a corolla 2–5 cm (0.8–2.0 in) diameter with five petal-like lobes. The fruit is a pair of follicles 2–4 cm (0.8–1.6 in) long and 3 mm (0.1 in) broad.[10][11][12][13]

Ecology

Cape periwinkles are of two types - foliage periwinkle (which often grows wild on cliffs) and annual periwinkle (Catharanthus roseus).[14] In the wild, C. roseus is an endangered plant; the main cause of decline is habitat destruction by slash and burn agriculture.[15] It is also, however, widely cultivated and is naturalised in subtropical and tropical areas of the world like Australia, Malaysia, India, Pakistan and Bangladesh.[10] It is so well adapted to growth in Australia, that it is listed as a noxious weed in Western Australia and the Australian Capital Territory,[16] and also in parts of eastern Queensland.[17]

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Pale Pink with Red Centre Cultivar

Cultivation

As an ornamental plant, it is appreciated for its hardiness in dry and nutritionally deficient conditions, popular in subtropical gardens where temperatures never fall below 5–7 °C (41–45 °F), and as a warm-season bedding plant in temperate gardens. It is noted for its long flowering period, throughout the year in tropical conditions, and from spring to late autumn, in warm temperate climates. Full sun and well-drained soil are preferred. Numerous cultivars have been selected, for variation in flower colour (white, mauve, peach, scarlet and reddish-orange), and also for tolerance of cooler growing conditions in temperate regions. Notable cultivars include 'Albus' (white flowers), 'Grape Cooler' (rose-pink; cool-tolerant), the Ocellatus Group (various colours), and 'Peppermint Cooler' (white with a red centre; cool-tolerant).[10]

Uses

The species has long been cultivated for herbal medicine and as an ornamental plant. In the UK it has gained the Royal Horticultural Society’s Award of Garden Merit[18] (confirmed 2017).[19] In Ayurveda (Indian traditional medicine) the extracts of its roots and shoots, though poisonous, are used against several diseases. In traditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin's lymphoma.[11] Many of the vinca alkaloids were first isolated from Catharanthus roseus,[20] including vinblastine and vincristine used in the treatment of leukemia[15] and Hodgkin's lymphoma.[11]

 src=
A periwinkle shrub

This conflict between historical indigenous use, and recent patents on C.roseus-derived drugs by western pharmaceutical companies, without compensation, has led to accusations of biopiracy.[21]

C. roseus can be extremely toxic if consumed orally by humans, and is cited (under its synonym Vinca rosea) in the Louisiana State Act 159.

C. roseus is used in plant pathology as an experimental host for phytoplasmas.[22] This is because it is easy to infect with a large majority of phytoplasmas, and also often has very distinctive symptoms such as phyllody and significantly reduced leaf size.[23]

Chemical constituents

Vinblastine and vincristine, chemotherapy medications used to treat several types of cancers, are found in the plant[24][25][26][27] and are biosynthesised from the coupling of the alkaloids catharanthine and vindoline.[28] The newer semi-synthetic chemotherapeutic agent vinorelbine, used in the treatment of non-small-cell lung cancer,[26][29] can be prepared either from vindoline and catharanthine[26][30] or from the vinca alkaloid leurosine,[31] in both cases via anhydrovinblastine.[30]

Rosinidin is the pink anthocyanidin pigment found in the flowers of C. roseus.[32]

Gallery

File:Catharanthus roseus in Kerala.jpeg Vinca Catharanthus roseus in Bangladesh.JPG Catharanthus roseus flower bud, Burdwan, West Bengal, India 12 09 2012.JPG Nithyaklalyani.jpg Nayantara.jpg Catharanthus roseus-1.jpg Catharanthus roseus Malaysia.jpg Nithyakalyani India.jpg Catharanthus roseus MHNT.BOT.2005.0962.jpg Catharanthus roseus Madagascar periwinkle White.JPG Catharanthus roseus Pacifica Burgundy Halo-Madagascar Periwinkle.JPG Catharanthus roseus-Red flowers of Madagascar Periwinkle 2.JPG Catharanthus Periwinkle.jpg Catharanthus roseus 001.jpg Catharanthus roseus 02.jpg Catharanthus roseus (1) 1200.jpg File:Catharanthus roseus Prague 2017 1.jpg File:Pollens of Catharanthus roseus.jpg|Pollen

Dark pink colour
Coming in different colours

>

References

  1. ^ "Catharanthus roseus". World Checklist of Selected Plant Families (WCSP). Royal Botanic Gardens, Kew. Retrieved 4 August 2019.
  2. ^ "Catharanthus roseus". Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States Department of Agriculture (USDA). Retrieved 4 August 2019.
  3. ^ Steenis ex Bakhuizen f., Blumea 6: 384. 1950.
  4. ^ a b G.Don, Gen. Hist. 4(1): 95. 1837.
  5. ^ Markgr., Adansonia, ser. 2. 12: 222. 1972.
  6. ^ Woodson, N. Amer. Fl. 29: 124. 1938.
  7. ^ Bakh. f.Blumea 6 (2): 384. 1950.
  8. ^ Markgr. Adansonia, ser. 2. 12: 222. 1972.
  9. ^ Steenis Trop. Nat. 25: 18. 1936.
  10. ^ a b c Huxley, A., ed. (1992). New RHS Dictionary of Gardening. Macmillan ISBN 0-333-47494-5.
  11. ^ a b c Flora of China: Catharanthus roseus
  12. ^ College of Micronesia: Catharanthus roseus
  13. ^ Jepson Flora: Catharanthus roseus
  14. ^ "Growing Periwinkle". Gardening knowhow official website. Gardening knowhow. Retrieved 4 June 2018.
  15. ^ a b DrugDigest: Catharanthus roseus Archived 2007-09-27 at the Wayback Machine
  16. ^ "Catharanthus roseus". Orpheus Island Research Station – James Cook University. Retrieved 2 November 2015.
  17. ^ "Factsheet – Catharanthus roseus". Queensland Government. Retrieved 2 November 2015.
  18. ^ "RHS Plantfinder - Catharanthus roseus". Retrieved 12 January 2018.
  19. ^ "AGM Plants - Ornamental" (PDF). Royal Horticultural Society. July 2017. p. 16. Retrieved 24 January 2018.
  20. ^ van Der Heijden, Robert; Jacobs, Denise I.; Snoeijer, Wim; Hallard, Didier; Verpoorte, Robert (2004). "The Catharanthus alkaloids: Pharmacognosy and biotechnology". Current Medicinal Chemistry. 11 (5): 607–628. doi:10.2174/0929867043455846. PMID 15032608.
  21. ^ Karasov, Corliss (2001). "Who Reaps the Benefits of Biodiversity?". Environmental Health Perspectives. 109 (12): A582–A587. doi:10.2307/3454734. JSTOR 3454734. PMC 1240518. PMID 11748021.
  22. ^ Marcone, C.; Ragozzino, A.; Seemuller, E. (1997). "Dodder transmission of alder yellows phytoplasma to the experimental host Catharanthus roseus (periwinkle)". Forest Pathology. 27 (6): 347–350. doi:10.1111/j.1439-0329.1997.tb01449.x.
  23. ^ Chang, Chung-Jan (1998). "Pathogenicity of Aster Yellows Phytoplasma and Spiroplasma citri on Periwinkle". Phytopathology. 88 (12): 1347–1350. doi:10.1094/PHYTO.1998.88.12.1347. PMID 18944838.
  24. ^ Gansäuer, Andreas; Justicia, José; Fan, Chun-An; Worgull, Dennis; Piestert, Frederik (2007). "Reductive C—C bond formation after epoxide opening via electron transfer". In Krische, Michael J. (ed.). Metal Catalyzed Reductive C—C Bond Formation: A Departure from Preformed Organometallic Reagents. Topics in Current Chemistry. 279. Springer Science & Business Media. pp. 25–52. doi:10.1007/128_2007_130. ISBN 978-3-540-72879-5.
  25. ^ Cooper, Raymond; Deakin, Jeffrey John (2016). "Africa's gift to the world". Botanical Miracles: Chemistry of Plants That Changed the World. CRC Press. pp. 46–51. ISBN 978-1-4987-0430-4.
  26. ^ a b c Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893–5914. doi:10.3390/molecules17055893. PMC 6268133. PMID 22609781.
  27. ^ Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John Wiley & Sons. pp. 157–159. ISBN 978-3-527-32669-3.
  28. ^ Hirata, K.; Miyamoto, K.; Miura, Y. (1994). "Catharanthus roseus L. (Periwinkle): Production of Vindoline and Catharanthine in Multiple Shoot Cultures". In Bajaj, Y. P. S. (ed.). Biotechnology in Agriculture and Forestry 26. Medicinal and Aromatic Plants. VI. Springer-Verlag. pp. 46–55. ISBN 978-3-540-56391-4.
  29. ^ Faller, Bryan A.; Pandi, Trailokya N. (2011). "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology. 5: 131–144. doi:10.4137/CMO.S5074. PMC 3117629. PMID 21695100.
  30. ^ a b Ngo, Quoc Anh; Roussi, Fanny; Cormier, Anthony; Thoret, Sylviane; Knossow, Marcel; Guénard, Daniel; Guéritte, Françoise (2009). "Synthesis and biological evaluation of Vinca alkaloids and phomopsin hybrids". Journal of Medicinal Chemistry. 52 (1): 134–142. doi:10.1021/jm801064y. PMID 19072542.
  31. ^ Hardouin, Christophe; Doris, Eric; Rousseau, Bernard; Mioskowski, Charles (2002). "Concise synthesis of anhydrovinblastine from leurosine". Organic Letters. 4 (7): 1151–1153. doi:10.1021/ol025560c. PMID 11922805.
  32. ^ Toki, Kenjiro; Saito, Norio; Irie, Yuki; Tatsuzawa, Fumi; Shigihara, Atsushi; Honda, Toshio (2008). "7-O-Methylated anthocyanidin glycosides from Catharanthus roseus". Phytochemistry. 69 (5): 1215–1219. doi:10.1016/j.phytochem.2007.11.005. PMID 18164044.

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Catharanthus roseus: Brief Summary

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 src= A white C. roseus flower

Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae. It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. It was formerly included in the genus Vinca as Vinca rosea.

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