Slime molds like Physarum polycephalum are useful for studying cytoplasmic streaming. They have also been used to study the biochemical events that surround mitosis, since all the nuclei in a medium-sized plasmodium divide in synchrony. It has been observed that they can find their way through mazes by spreading out and choosing the shortest path, an interesting example of information processing without a nervous system. Myxomycete plasmodia have also been used to study the genetics of asexual cell fusion. The giant size of the plasmodial cells allows for easy evaluation of complete or partial cell fusion.
In 2006, researchers at the University of Southampton and the University of Kobe reported that they had built a six-legged robot whose movement was remotely controlled by a Physarum slime mold. The mold directed the robot into a dark corner most similar to its natural habitat.
Members of the Mycetozoa group are able to undergo sexual reproduction either by heterothallic or homothallic mating An analysis of meiosis-related genes in the Dictyostelium discoideum genome revealed that 36 of the 44 genes tested were present in the genome. One gene, Spo11, was absent in the Mycetozoa, raising questions about the assumed universal role of Spo11 as an initiator of meiosis.