Greenhouse frogs are native to Cuba, Isla de Pinos, the Cayman Islands including Grand Cayman and Cayman Brac, and the Bahama islands including Grand Bahama, Great Abaco, New Providence, Eleuthera, Andros, the Berry Islands, the Bimini Islands, the Exuma Cays, Green Cay, Cat, Long, and San Salvador (Schwartz 1974). Greenhouse frogs have been introduced in Florida, Louisiana near New Orleans (Dundee and Rossman 1989; Conant and Collins 1991), Georgia (Winn et al. 1999), Hawaii (Kraus et al. 1999), Guam (Christy et al. 2007), Jamaica (Pough et al. 1977), and Honduras (McCranie et al. 2008). There are also records from the Mexican mainland (Veracruz), although this species has not been seen there since the 1970s (Schwartz 1974; Hedges et al. 2004). The altitudinal range is from sea level to 727 m asl (Hedges et al. 2004).
These frogs can be found in a variety of terrestrial habitats, including forests, caves, gardens, and urban areas. On Grand Cayman it inhabits arboreal bromeliads (Hedges et al. 2004).