Wikipedia

Chlamydophila abortus

Chlamydophila abortus is a species in Chlamydiae that causes abortion and fetal death in mammals, including humans. Chlamydophila abortus was previously classified as Chlamydia psittaci along with all Chlamydiae except Chlamydia trachomatis. This was based on a lack of evident glycogen production and on resistance to the antibiotic sulfadiazine. In 1999 C. psittaci and C. abortus were recognized as distinct species based on differences of pathogenicity and DNA-DNA hybridization.[1]

C. abortus is endemic among ruminants and has been associated with abortion in a horse, a rabbit, guinea pigs, mice, pigs and humans. Infected females shed bacteria near the time of ovulation, so C. abortus is transmitted orally and sexually among mammals. All C. abortus strains were isolated or PCR-amplified from placenta or fetal organs after spontaneous abortion. C. abortus infection generally remains inapparent until an animal aborts late in gestation or gives birth to a weak or dead foetus.

C. abortus has not been isolated from birds.

Genome structure[edit]

C. abortus has a relativelly small genome that contains 1.14 Mbp with 961 protein coding genes.[2]

Further Reading[edit]

  • Longbottom, D; Livingstone, M (March 2006). "Vaccination Against Chlamydial Infections of Man and Animals". The Veterinary Journal 171 (2): 263–275. doi:10.1016/j.tvjl.2004.09.006. 

References[edit]

  1. ^ Everett, KD.; Bush, RM.; Andersen, AA. (Apr 1999). "Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms". Int J Syst Bacteriol. 49 Pt 2: 415–40. PMID 10319462. 
  2. ^ Thomson, NR.; Yeats, C.; Bell, K.; Holden, MT.; Bentley, SD.; Livingstone, M.; Cerdeño-Tárraga, AM.; Harris, B. et al. (May 2005). "The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation". Genome Res 15 (5): 629–40. doi:10.1101/gr.3684805. PMC 1088291. PMID 15837807. 
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