Streptococcus is a genus of spherical Gram-positive bacteria belonging to the phylum Firmicutes and the lactic acid bacteria group. Cellular division occurs along a single axis in these bacteria, and thus they grow in chains or pairs, hence the name — from Greek στρεπτος streptos, meaning easily bent or twisted, like a chain (twisted chain). Contrast this with staphylococci, which divide along multiple axes and generate grape-like clusters of cells. Most streptococci are oxidase- and catalase-negative, and many are facultative anaerobes.
Streptococcus milleri group
|Streptococcus milleri group|
|Classification and external resources|
|MeSH||B03.510.400.800.872.875.475, B03.510.550.737.872.875.475, B03.510.400.800.872.875.475,|
Streptococcus milleri is an unofficial name applied to a group of basically similar viridans streptococci species showing various hemolytic, serological, and physiological characteristics. The species name Streptococcus anginosus has recently been recognized as the approved name for these organisms. They have been implicated as etiologic agents in a variety of serious purulent infections, but because of their heterogeneous characteristics, these organisms may be unrecognized or misidentified by clinical laboratorians. The unique characteristic of them from other pathogenic streptococci, such as S. pyogenes and S. agalactiae, is their ability to cause abscesses.
- Streptococcus anginosus
- Streptococcus constellatus
- Streptococcus intermedius
These non-hemolytic viridans streptococci were first described by Guthof in 1956 after being isolated from dental abscesses. He named these organisms "Streptococcus milleri" in honor of the microbiologist W. D. Miller.
The organisms were subsequently recognized as normal flora of the human oral cavity and gastrointestinal tract with the ability to cause abscesses and systemic infections.
- Streptococcus milleri group at the US National Library of Medicine Medical Subject Headings (MeSH)
- Ruoff, K L (Jan 1988). "Streptococcus anginosus ("Streptococcus milleri"): the unrecognized pathogen". Clinical Microbiology Reviews 1 (1): 102–108. doi:10.1128/CMR.1.1.102. PMC PMC358032. PMID 3060239.
- Gossling, J (1988 Mar-Apr). "Occurrence and pathogenicity of the Streptococcus milleri group". Reviews of infectious diseases 10 (2): 257–85. doi:10.1093/clinids/10.2.257. PMID 3287560.
- Rashid, R. M.; Salah, W.; Parada, J. P. (1 February 2007). "'Streptococcus milleri' aortic valve endocarditis and hepatic abscess". Journal of Medical Microbiology 56 (2): 280–282. doi:10.1099/jmm.0.46781-0.
- Whiley, RA; Beighton, D (1991 Jan). "Emended descriptions and recognition of Streptococcus constellatus, Streptococcus intermedius, and Streptococcus anginosus as distinct species". International journal of systematic bacteriology 41 (1): 1–5. doi:10.1099/00207713-41-1-1. PMID 1995029.
- Verrall, R (1986 Nov). "The Streptococcus milleri group". Infection control : IC 7 (11): 558–60. JSTOR 30146431. PMID 3640746.
- Mejàre, B; Edwardsson, S (1975 Nov). "Streptococcus milleri (Guthof); an indigenous organism of the human oral cavity". Archives of oral biology 20 (11): 757–62. doi:10.1016/0003-9969(75)90048-5. PMID 1061530.
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Streptococcus is a genus of spherical Gram-positive bacteria belonging to the phylum Firmicutes and the lactic acid bacteria group. Cellular division occurs along a single axis in these bacteria, and thus they grow in chains or pairs, hence the name — from Greek στρεπτος streptos, meaning easily bent or twisted, like a chain (twisted chain).
Pathogenesis and classification 
In addition to streptococcal pharyngitis (strep throat), certain Streptococcus species are responsible for many cases of pink eye, meningitis, bacterial pneumonia, endocarditis, erysipelas and necrotizing fasciitis (the 'flesh-eating' bacterial infections). However, many streptococcal species are nonpathogenic, and form part of the commensal human microbiome of the mouth, skin, intestine, and upper respiratory tract. Furthermore, streptococci are a necessary ingredient in producing Emmentaler ("Swiss") cheese.
Species of Streptococcus are classified based on their hemolytic properties. Alpha hemolytic species cause oxidization of iron in hemoglobin molecules within red blood cells, giving it a greenish color on blood agar. Beta hemolytic species cause complete rupture of red blood cells. On blood agar, this appears as wide areas clear of blood cells surrounding bacterial colonies. Gamma-hemolytic species cause no hemolysis.
Beta-hemolytic streptococci are further characterised via Lancefield serotyping, which describes specific carbohydrates present on the bacterial cell wall. There are 20 described serotypes, named Lancefield groups A to V (excluding I and J).
In the medical setting, the most important groups are the alpha-hemolytic streptococci S. pneumoniae and Streptococcus Viridans-group, and the beta-hemolytic streptococci of Lancefield groups A and B (also known as “Group A strep” and “Group B strep”).
- S. pneumoniae (sometimes called Pneumococcus), is a leading cause of bacterial pneumonia and occasional etiology of otitis media, sinusitis, meningitis and peritonitis.
Inflammation is thought to be the major cause of how pneumococcus causes disease, hence the tendency of diagnoses associated with it to involve inflammation.
The Viridans group: alpha-hemolytic 
- Streptococcus viridans is a pseudotaxonomic non-Linnean term for a large group of commensal streptococcal bacteria that are either α-hemolytic, producing a green coloration on blood agar plates (hence the name "viridans", from Latin "vĭrĭdis", green), or nonhemolytic. They possess no Lancefield antigens.
Group A 
S. pyogenes, also known as Group A Streptococcus (GAS), is the causative agent in a wide range of Group A streptococcal infections. These infections may be non-invasive or invasive. The non-invasive infections tend to be more common and less severe. The most common of these infections include streptococcal pharyngitis (strep throat) and impetigo. Scarlet fever is also a non-invasive infection, but has not been as common in recent years.
The invasive infections cause by Group A β-hemolytic streptococcus tend to be more severe and less common. This occurs when the bacterium is able to infect areas where it is not usually found, such as the blood and the organs. The diseases that may be caused as a result of this include streptococcal toxic shock syndrome (STSS), necrotizing fasciitis (NF), pneumonia, and bacteremia.
Additional complications may be caused by GAS, namely acute rheumatic fever and acute glomerulonephritis. Rheumatic fever, a disease that affects the joints, kidneys, and heart valves, is a consequence of untreated strep A infection caused not by the bacterium itself. Rheumatic fever is caused by the antibodies created by the immune system to fight off the infection cross-reacting with other proteins in the body. This "cross-reaction" causes the body to essentially attack itself and leads to the damage above. Globally, GAS has been estimated to cause more than 500,000 deaths every year, making it one of the world's leading pathogens. Group A Streptococcus infection is generally diagnosed with a Rapid Strep Test or by culture.
Group B 
S. agalactiae, or GBS, causes pneumonia and meningitis in neonates and the elderly, with occasional systemic bacteremia. They can also colonize the intestines and the female reproductive tract, increasing the risk for premature rupture of membranes during pregnancy, and transmission of the organism to the infant. The American College of Obstetricians and Gynecologists, American Academy of Pediatrics and the Centers for Disease Control recommend that all pregnant women between 35 and 37 weeks gestation should be tested for GBS. Women who test positive should be given prophylactic antibiotics during labor, which will usually prevent transmission to the infant.
In the UK, clinicians have been slow to implement the same standards as the US, Australia and Canada. In the UK, only 1% of maternity units test for the presence of Group B Streptococcus. Although the Royal College of Obstetricians and Gynaecologists issued risk-based guidelines in 2003 (due for review 2006), the implementation of these guidelines has been patchy. As a result, over 75 infants in the UK die each year of GBS-related disease, and another 600 or so suffer serious infection, most of which could be prevented; however, this is yet to be substantiated by randomized, controlled trial in the UK setting and, given the evidence for the efficacy of testing and treating from other countries, it may be that the large-scale trial necessary would receive neither funding nor ethics approval.
Group C 
This group includes S. equi, which causes strangles in horses, and S. zooepidemicus - S. equi is a clonal descendent or biovar of the ancestral S. zooepidemicus - which causes infections in several species of mammals, including cattle and horses. Streptococcus dysgalactiae is also a member of Group C, β-haemolytic streptococci that can cause pharyngitis and other pyogenic infections similar to Group A streptococci.
Group D (enterococci) 
Many former Group D streptococci have been reclassified and placed in the genus Enterococcus (including Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, and Enterococcus avium). For example, Streptococcus faecalis is now Enterococcus faecalis.
Nonhemolytic streptococci rarely cause illness. However, weakly hemolytic group D beta-hemolytic streptococci and Listeria monocytogenes (which is actually a Gram-positive bacillus) should not be confused with nonhemolytic streptococci.
Group F streptococci 
Group F streptococci were first described in 1934 by Long and Bliss amongst the "minute haemolytic streptococci". They are also known as Streptococcus anginosus (according to the Lancefield classification system) or as members of the S. milleri group (according to the European system).
Group G streptococci 
These streptococci are usually, but not exclusively, beta-hemolytic. Streptococcus canis is an example of a GGS which is typically found on animals, but can cause infection in humans.
Group H streptococci 
Group H streptococci is a very rare infection caused by the herptitis bacteria found in medium sized canines. Group H streptococci rarely causes illness unless a human has direct contact with the mouth of a canine. One of the most common ways this can be spread is human to canine, mouth-to-mouth contact. However, canine may lick the humans hand and infection can be spread as well.
Molecular taxonomy and phylogenetics 
Streptococci have been divided into six groups on the basis of their 16S rDNA sequences: Anginosus, Bovis, Mitis, Mutans, Pyogenes and Salivarius. The 16S groups have been confirmed by whole genome sequencing (see figure). The important pathogens S. pneumoniae and S. pyogenes belong to the Mitis and Pyogenes groups, respectively, while the causing agent of dental caries,Streptococcus mutans, is basal to the Streptococcus group.
The genomes of hundreds of species have been sequenced. Most Streptococcus genomes are 1.8 tp 2.3 Mb in size and encode 1,700 to 2,300 proteins. Some important genomes are listed in the table. The four species shown in the table (pyogenes, agalactiae, pneumoniae, and mutans) have an average pairwise protein sequence identity of about 70%.
|feature||S. pyogenes||S. agalactiae||S. pneumoniae||S. mutans|
- See List of antibiotics.
See also 
- "Result of detail taxonomy information". TXSearch Taxonomy Retrieval. DNA Data Bank of Japan. 19 February 2010. Retrieved 30 March 2010.
- Ryan KJ, Ray CG, ed. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
- Facklam R (October 2002). "What happened to the streptococci: overview of taxonomic and nomenclature changes". Clin. Microbiol. Rev. 15 (4): 613–30. doi:10.1128/CMR.15.4.613-630.2002. PMC 126867. PMID 12364372.
- Patterson MJ (1996). Streptococcus. In: Baron's Medical Microbiology (Baron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.
- Facklam R (2002). "What happened to the streptococci: overview of taxonomic and nomenclature changes". Clin Microbiol Rev 15 (4): 613–30. doi:10.1128/CMR.15.4.613-630.2002. PMC 126867. PMID 12364372.
- Cohen-Poradosu, Ronit; Dennis L. Kasper (2007). "Group A Streptococcus Epidemiology and Vaccine Implications". Clinical Infectious Diseases.
- "Streptococcal Infections (Invasive Group A Strep)". New York City Department of Health and Mental Hygiene. Retrieved 21 November 2012.
- Schrag S, Gorwitz R, Fultz-Butts K, Schuchat A (2002). "Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC". MMWR Recomm Rep 51 (RR-11): 1–22. PMID 12211284.
- Hughes, RG, et al. Prevention of Early Onset Neonatal Group B Streptococcal Disease. Royal College of Obstetricians and Gynaecologists.
- "Group B Strep Support Home Page". Group B Strep Support. 2007-01-09.
- "RCOG: Preventing group B streptococcus infection in new born babies". RCOG. 2006-02.
- Harrington D, Sutcliffe I, Chanter N (2002). "The molecular basis of Streptococcus equi infection and disease". Microbes Infect 4 (4): 501–10. doi:10.1016/S1286-4579(02)01565-4. PMID 11932201.
- Köhler W (June 2007). "The present state of species within the genera Streptococcus and Enterococcus". International Journal of Medical Microbiology 297 (3): 133–50. doi:10.1016/j.ijmm.2006.11.008. PMID 17400023.
- Whitworth JM (November 1990). "Lancefield group F and related streptococci" (PDF). J. Med. Microbiol. 33 (3): 135–51. doi:10.1099/00222615-33-3-135. PMID 2250284.
- Kawamura Y, Hou XG, Sultana F, Miura H, Ezaki T (1995) Determination of 16S rRNA sequences of Streptococcus mitis and Streptococcus gordonii and phylogenetic relationships among members of the genus Streptococcus. Int J Syst Bacteriol 45: 406–408
- Streptococcus genomes and related information at PATRIC
- Ferretti, J. J.; Ajdic, D.; McShan, W. M. (2004). "Comparative genomics of streptococcal species". The Indian journal of medical research. 119 Suppl: 1–6. PMID 15232152.
Streptococcus mitis is a mesophilic alpha-hemolytic species of Streptococcus that inhabits the human mouth. It is a Gram positive, coccus, facultative anaerobe and catalase negative. It can cause endocarditis. It has been widely reported that this organism survived for over two years on the Surveyor 3 probe on the moon; but some NASA scientists suggest this may be a result of contamination during or after return of Surveyor parts to Earth, as the person assembling the camera may have sneezed.
Previously know as Streptococcus mitior.
- Lamas, C. C.; Eykyn, S. J. (2003). "Blood culture negative endocarditis: Analysis of 63 cases presenting over 25 years". Heart (British Cardiac Society) 89 (3): 258–262. doi:10.1136/heart.89.3.258. PMC 1767579. PMID 12591823. .
- http://lsda.jsc.nasa.gov/scripts/experiment/exper.cfm?exp_index=1651. NASA
Viridans Streptococci is a pseudotaxonomic non-Linnean term for a large group of commensal streptococcal bacteria that are either α-hemolytic, producing a green coloration on blood agar plates (hence the name "viridans", from Latin "vĭrĭdis", green), or nonhemolytic. They possess no Lancefield antigens.
In general, pathogenicity is low.
Viridans streptococci can be differentiated from Streptococcus pneumoniae using an optochin test, as Viridans streptococci are optochin resistant; they also lack either the polysaccharide-based capsule typical of S. pneumoniae or the Lancefield antigens of the pyogenic members of the genus.
|Viridans streptococci||Streptococcus pneumoniae|
|Solubility in bile||Insoluble||Soluble|
|Fermentation of inulin||Not a fermenter||Fermenter with acid production|
|Sensitivity to optochin||Not sensitive||Sensitive|
|Pathogenicity to mice||Nonpathogenic||Pathogenic|
The organisms are most abundant in the mouth, and one member of the group, S. mutans, is the etiologic agent of dental caries in most cases and populations. Others may be involved in other mouth or gingival infections.
If they are introduced into the bloodstream, they have the potential of causing endocarditis, particularly in individuals with damaged heart valves. They are the most common causes of subacute bacterial endocarditis.
Viridans streptococci have the unique ability to synthesize dextrans from glucose, which allows them to adhere to fibrin-platelet aggregates at damaged heart valves. This mechanism underlies their ability to cause subacute valvular heart disease following their introduction into the bloodstream (e.g., following dental extraction).
- See List of antibiotics.
- Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 293–4. ISBN 0-8385-8529-9.
- Viridans+Streptococci at the US National Library of Medicine Medical Subject Headings (MeSH)
- Patterson MJ (1996). "Streptococcus". Baron's Medical Microbiology (Baron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.chapter.824.
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