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Hydrangea quercifolia is suceptible to disease if grown in humid to wet conditions (Mmbaga & Oliver, 2007: 210-211). Hydrangea quercifolia may develop a foliar disease characterized by angular dark spots on the leaves, caused by a bacterium Xanthomonas campestris. Japanese beetle Popillia japonica also feed on the plant. Kaolin clay was determined to be an environmentally-friendly and effective treatment (Mmbaga & Oliver, 2007: 216).
The lovebug Plecia nearctica is attracted to the blooms of H. quercifolia due to the presence of the compound phenylacetaldehyde (PAA)(Steven et al. 2007: 200). PAA could be used to help attract and then trap the pest (Steven et al. 2007: 200).
Mmbaga, M., & Oliver, J. 2007. Effect of biopesticides on foliar diseases and Japanese beetle (Popillia japonica) adults in roses (Rosa spp.), oakleaf hydrangea (Hydrangea quercifolia), and crapemyrtle (Lagerstroemia indica). Scientific Journal of the International Society of Arborlculture 33: 210–219.