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DistributionSpreading dogbane is widely distributed throughout North America. It occurs in every U.S. state except Hawaii, Kansas, and the southeastern states of Louisiana, Mississippi, Florida, and South Carolina . Spreading dogbane can be found in most Canadian provinces  and occurs in Mexico . A. a. var. incanum can be found scattered throughout Nova Scotia  and A. a. var. pumilum is found in west-central Montana . Intermediate dogbane is found primarily in areas where spreading dogbane and Indian hemp habitats overlap [137,189,190,191]. Plants database provides a distributional map for spreading dogbane.