Nicotiana clevelandii is a species of wild tobacco known by the common name Cleveland's tobacco. It is native to northwestern Mexico and the southwestern United States in California and Arizona, where it grows in the Sonoran Desert and in coastal canyons. It is a glandular and sparsely hairy annual herb producing a slender stem up to about 60 centimeters in maximum height. The leaf blades may be 18 centimeters long, the lower ones borne on petioles. The inflorescence bears white or green-tinged flowers with tubular throats around 2 centimeters long, their bases enclosed in pointed sepals which are unequal in length. The flower face is about a centimeter wide with five mostly white lobes. The fruit is a capsule about half a centimeter long.

This plant was used for a variety of medicinal purposes and smoked in rituals by the Cahuilla.^[1]

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