Brief Summary

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Brief Summary

Human baylisascariasis is caused by larvae of Baylisascaris procyonis, an intestinal nematode (roundworm) of raccoons. Raccoons infected with B. procyonis appear to be common in the Middle Atlantic, Midwest, and Northeast regions of the United States and are well documented in California and Georgia. Domestic dogs can serve as alternative definitive hosts. Proven human cases have been reported in California, Oregon, New York, Pennsylvania, Illinois, Michigan, and Minnesota, with a suspected case in Missouri. This parasite has been introduced along with its host to Europe and Japan. More than 100 species of animals , including humans, have been known to develop neurological disease as a result of infection with larvae of this parasite. Most known cases of human baylisascariasis have resulted in lasting neurological sequelae or death.

Baylisascaris procyonis completes its life cycle in raccoons, with humans acquiring the infection as accidental hosts (dogs serve as alternate definitive hosts, as they can harbor patent and shed eggs). Unembryonated eggs are shed in the environment, where they take 2 to 4 weeks to embryonate and become infective. Raccoons can be infected by ingesting embryonated eggs from the environment. Additionally, over 100 species of birds and mammals (especially rodents) can act as paratenic ("transport") hosts for this parasite: eggs ingested by these paratenic hosts hatch and larvae penetrate the gut wall and migrate into various tissues where they encyst. The life cycle is completed when raccoons eat these hosts. The larvae develop into egg-laying adult worms in the small intestine and eggs are eliminated in raccoon feces. Humans become accidentally infected when they ingest infective eggs from the environment; typically this occurs in young children playing in the dirt. Migration of the larvae through a wide variety of tissues (liver, heart, lungs, brain, eyes) results in VLM (visceral larva migrans) and OLM (ocular larva migrans) syndromes, similar to toxocariasis. In contrast to Toxocara larvae, Baylisascaris larvae continue to grow during their time in the human host. Tissue damage and the signs and symptoms of baylisascariasis are often severe because of the size of Baylisascaris larvae, their tendency to wander widely, and the fact that they do not readily die. Diagnosis is usually made by serology, or by identifying larvae in biopsy or autopsy specimens.

(Centers for Disease Control Parasites and Health website; Lee et al. 2010 and references therein)


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