Aquilegia coerulea shows considerable geographic variation in flower color and in size of different floral organs, reflecting adaptation to different pollinators in different parts of its range (R. B. Miller 1981). Four weakly differentiated varieties are recognized.

Aquilegia coerulea var. coerulea and A . coerulea var. ochroleuca intergrade to some extent; northwestern populations of var. coerulea often contain individuals with pale flowers, and eastern populations of var. ochroleuca often contain blue-flowered plants.

The Gosivte tribe chewed the seeds of Aquilegia coerulea or used an infusion made from the roots to treat abdominal pains or as a panacea (D. E. Moerman 1986).

Most authors have spelled the epithet "caerulea"; "coerulea" is the original spelling.

Columbine (as Aquilegia caerulea ) is the state flower of Colorado.