Conus serranegrae is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies.
Like all species within the genus Conus, these snails are predatory and venomous. They are capable of "stinging" humans, therefore live ones should be handled carefully or not at all.
Shell small, spire short. White background with a cream to light brown reticulated pattern, sometimes zigzag. Often, the colors appear to form spiral bands. Shell up to 18 mm.
Known only from the type locality: Serra Negra, Sal, Cape Verde. In shallow water. It is a species at high extinction risk due to its limited distribution.