Overview

Brief Summary

Aeromonas hydrophila is a ubiquitous gram-negative aquatic bacterium classified within the phylum proteobacteria.  It lives in fresh or brackish water worldwide, and is found in large numbers especially in warm conditions e.g. 25-35oC (77-95oF).  This bacterium is hearty and tolerates aerobic and anaerobic environments, a wide temperature range (it can grow at 4oC), chlorination, pollution, and is also resistant to most common antibiotics.

Aeromonas hydrophila are rods with rounded ends, usually between 0.3 – 1 micrometer in width, 1 – 3 micrometers in length and motile via polar flagella.  While it makes up part of the normal, harmless bacterial flora in most aquatic ecosystems, this bacterium is opportunistically pathenogenic in aquatic animals, flaring into disease especially in animals that are stressed, disturbed or unhealthy.  Aeromonas hydrophila is the most common cause of red leg, a disease contracted by amphibians which causes lesions on their back legs and internal, sometimes fatal hemorrhaging.  Fish infected with Aeromonas hydrophila, develop ulcers, tail and fin rot, and other symptoms and can die quickly after contracting symptoms.  

While not as pathogenic in humans as it is in fish and amphibians (it was not associated with human disease until 1968), when ingested in large quantities from contaminated water or foods it may cause gastroenteritis, especially in young children and people who have compromised immune systems.  There is some disagreement about what the role of A. hydrophila is in causing gastroenteritis, however.  Large outbreaks of Aeromonas-caused gastric illness have never been reported and the frequency of Aeromonas-related disease in the United States is unclear.  Aeromonas hydrophila can also enter the body when open skin lacerations are exposed to sources of the bacteria, in these case infection can cause skin inflammation, septicemia (dangerous systemic infection), and rarely it has caused necrotizing fasciitis (flesh-eating disease).  An unusual 2012 case of necrotizing fasciitis in a healthy 24-year-old brought public attention to A. hydrophila (Lynch 2012), but this bacteria causes far fewer cases of necrotizing fasciitis than does the Strep A bacterium.

Aeromonas hydrophila was one of the first species described from genus Aeromonas; isolated from humans and animals in the 1950s.  Interest in the genus has jumped hugely in the last 20 years, and since 1980 20 new Aeromonas names were given standing in the literature (LPSN bacterio.net).  At least 13 “genospecies” are recognized; it is difficult to distinguish species beyond their species complexes. Not all of these are associated with disease, far less is known about most other species of Aeromonas. The full genome of A. hydrophila was sequenced in 2006.

(CDC 1990; US EPA 2012; Janda and Abbott 2010; LPSN bacterionet, web; Lynch 2012; US FDA 2013; WHO 2002, 2006)

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Wikipedia

Aeromonas hydrophila


Aeromonas hydrophila is a heterotrophic, Gram-negative, rod-shaped bacterium mainly found in areas with a warm climate. This bacterium can be found in fresh or brackish water. It can survive in aerobic and anaerobic environments, and can digest materials such as gelatin and hemoglobin. A. hydrophila was isolated from humans and animals in the 1950s. It is the most well known of the species of Aeromonas. It is resistant to most common antibiotics and cold temperatures.

Structure[edit]

A. hydrophila bacteria are Gram-negative, straight rods with rounded ends (bacilli to coccibacilli shape) usually from 0.3 to 1.0 μm in width, and 1.0 to 3.0 μm in length. They can grow at temperatures as low as 4°C. These bacteria are motile by a polar flagellum.

Pathology[edit]

Because of its structure, it is very toxic to many organisms. When it enters the body of its victim, it travels through the bloodstream to the first available organ. It produces aerolysin cytotoxic enterotoxin that can cause tissue damage. A. hydrophila, A. caviae, and A. sobria are all considered to be opportunistic pathogens, meaning they rarely infect healthy individuals. A. hydrophila is widely considered a major fish and amphibian pathogen,[1] and its pathogenicity in humans has been recognized for decades.[2]

Pathogenic mechanism[edit]

The pathogenicity of Aeromonas species was believed to be mediated by a number of extracellular proteins such as aerolysin, lipase, chitinase, amylase, gelatinase, hemolysins, and enterotoxins. However, the pathogenic mechanisms are unknown. The recently proposed type-III secretion system (TTSS) has been linked to Aeromonas pathogenesis. TTSS is a specialized protein secretion machinery that exports virulence factors directly to host cells. These factors subvert normal host cell functions to the benefit of invading bacteria. In contrast to the general secretory pathway, the TTSS is triggered when a pathogen comes in contact with host cells. ADP-ribosylation toxin is one of the effector molecules secreted by several pathogenic bacteria and translocated through the TTSS and delivered into the host cytoplasm, which leads to interruption of the NF-κB pathway, cytoskeletal damage, and apoptosis. This toxin has been characterized in A. hydrophila (human diarrhoeal isolate), A. salmonicida (fish pathogen), and A. jandaei GV17, a pathogenic strain which can cause disease both in humans and fish.

Occurrence of exposure[edit]

A. hydrophila infections occur most often during environmental changes, stressors, changes in temperature, in contaminated environments, and when an organism is already infected with a virus or another bacterium. It can also be ingested through food products contaminated with the bacterium, such as seafood, meats, and even certain vegetables such as sprouts. It can also be transmitted by leeches.[3]

Fish and amphibians[edit]

A. hydrophila is associated with diseases mainly found in freshwater fish and amphibians, because these organisms live in aquatic environments. It is linked to a disease found in frogs called red leg, which causes internal, sometimes fatal hemorrhaging. When infected with A. hydrophila, fish develop ulcers, tail rot, fin rot, and hemorrhagic septicemia. Hemorrhagic septicaemia causes lesions that lead to scale shedding, hemorrhages in the gills and anal area, ulcers, exophthalmia, and abdominal swelling.

Human diseases[edit]

A. hydrophila is not as pathogenic to humans as it is to fish and amphibians. One of the diseases it can cause in humans, gastroenteritis, occurs mostly in young children and people who have compromised immune systems or growth problems. This bacterium is linked to two types of gastroenteritis. The first type is a disease similar to cholera, which causes rice-water diarrhea. The other type is dysenteric gastroenteritis, which causes loose stools filled with blood and mucus. Dysenteric gastroenteritis is the most severe out of the two types, and can last for several weeks. A. hydrophila is also associated with cellulitis. It also causes diseases such as myonecrosis and eczema in people with compromised or suppressed (by medication) immune systems.[4] In very rare cases, A. hydrophila can cause necrotizing fasciitis.[5]

Outbreaks[edit]

Though A. hydrophila can cause serious diseases, no serious outbreaks have been reported. An outbreak occurred inside the intestinal tracts of lizards in Puerto Rico.[6] Some 116 different strains were found in the lizards. On May 1, 1988, a small outbreak happened in California. The 225 isolates in 219 patients caused their hospital admissions. Confidential morbidity report cards were used to report the cases to the local health departments. Investigations were conducted, and reports were sent to the California Department of Health Services for diagnosis and methods in treatment.

Treatments[edit]

A. hydrophila can be eliminated using a 1% sodium hypochlorite solution or 2% calcium hypochlorite solution.

Brage et al., 1990 recommends fluoroquinolone administration as a prophylactic treatment during medicinal leech application.[7]

Antibiotics such as chloramphenicol, florenicol, tetracycline, sulfonamide, nitrofuran derivatives, and pyrodinecarboxylic acids are used to eliminate and control the infection of A. hydrophila.

Terramycin is placed in fish food during hatchery operations as another chemotherapeutic agent in preventing A. hydrophila.


References[edit]

  1. ^ Prevalence and distribution of Aeromonas hydrophila in the United States
  2. ^ Clinical and microbiological features of Aeromonas hydrophila-associated diarrhea
  3. ^ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC267578/
  4. ^ Evolving concepts regarding the genus Aeromonas: an expanding panorama of species, disease presentations, and unanswered questions
  5. ^ Necrotizing fasciitis caused by Aeromonas hydrophila
  6. ^ Fulton, MacDonald. "The Bacterium Aeromonas hydrophila from Lizards of the genus Anolis in Puerto Rico". Louisiana State University Medical Center, New Orleans.
  7. ^ Braga A, Lineaweaver WC, Whitney TM, Follansbee S, Buncke HJ. Sensitivities of aerononas hydrophila cultured from medicinal leeches to oral antibiotics. J Reconstr Microsurg. 1990; 6(2):135-137
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