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Heliconius cydno is a polytypic species ranging from southern Mexico to western Ecuador, with a number of closely-related entities (including H. pachinus, H. heurippa, H. timareta and H. tristero) that have been described as separate species but may be differentiated geographical races or the results of introgressive hybridization. Patterns of gene flow between races of H. cydno and races of its close relative H. melpomene are the subject of much current research (e. g., Mavarez et al. 2006).
Heliconius cydno is involved in Müllerian mimicry with Heliconius sapho over most of its range, and also with Heliconius eleuchia in western Colombia and Ecuador. In the upper Cauca valley of Colombia, there are no corresponding races of either of the latter species, and H. cydno weymeri is comimetic with H. erato chestertonii, whose usual mimic H. melpomene is also not present there.
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