Pithecia irrorata has a wide range, occurring south of the Solimöes, west of the Tapajós Madeira, and north of the Guaporé rivers in Brazil. It occurs narrowly in the north-west of Bolivia and in eastern Peru, north of the Madre de Dios. There are two recognized subspecies:

P. irrorata irrorata is wide ranging in the upper, south-western Amazon of Brazil. It occurs north of the Madre de Dios in the Manú National Park in Peru, and in north-west Bolivia.

P. irrorata vanzolinii has a restricted range in Brazil between the upper Rio Juruá and its south bank tributary, the Rios Tarauacá-Embira in the states of Acre and Amazonas (Hershkovitz 1987).