Agave deserti occurs on rocky or gravelly soils in the Lower Colorado River Valley subdivision of the Sonoran Desert. The range extends marginally into the Arizona upland and the Mojave Desert. The Deserticolae family is present around the Gulf of California, almost throughout all of the Sonoran Desert. Agave deserti concentrations can be found in the high deserts of Southern California, Arizona and northern Baja California. In California Agave deserti is found in the Anza Borrego Desert, Palm desert and at arroyos below the western slopes of the San Bernardino Mountains. There is also a small concentration at a base level of the Providence Mountains in the Mojave Desert.