Furcifer labordi is a sexually dimorphic chameleon species with an unusual annual life cycle. The entire population has a synchronized life history – all F. labordi individuals in a generation hatch, mature, and die in synchrony over the course of a single year. This species is unique among tetrapods because of its short post-hatching lifespan, lasting 4-5 months, and because it consequently spends more time inside of the egg than outside of it. Furcifer labordi inhabits coastal lowlands in southwest Madagascar, where it can be found on low perches (1-2 m above the ground) in bushes and trees. Common predators of this species include birds and snakes.

The social interactions of Furcifer labordi are physically aggressive, perhaps because of the high similarity in age and body size between individuals in a population. Several secondary sex characteristics are present. Most notably, males are distinguished by a high cranial casque and a prominent rostral process. Females are more colorful than males but their casques and rostral processes are highly reduced. The limited range and unique life cycle of this species may render it especially vulnerable to threats such as habitat destruction.