Lifespan, longevity, and ageing
Maximum longevity: 0.04 years (captivity) Observations: The budding yeast suffers from clonal senescence in which each cell can only reproduce a limited amount of times. The accumulation of extrachromosomal ribosomal DNA circles has been suggested as a possible causal mechanism (Sinclair and Guarente 1997). It is also possible to measure chronological lifespan in yeast in terms of stationary phase survival. Several genes have been identified that regulate clonal senescence or chronological lifespan (Kaeberlein et al. 2001), but because these two measurements are fundamentally different some genes have been shown to have opposite effects on them (Kennedy et al. 2005).
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