Mottled sculpin have been reported as prey by Salvelinus fontinalis, Salmo trutta, Esox lucius, Mergus merganser, and Nerodia sipedon. They are also likely prey of wading birds, such as herons.
- brook trout (Salvelinus_fontinalis)
- brown trout (Salmo_trutta)
- northern pike (Esox_lucius)
- common mergansers (Mergus_merganser)
- water snakes (Nerodia_sipedon)
- herons (Ardeidae)
Anti-predator Adaptations: cryptic
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