Coccidioides is a genus of dimorphic ascomycete, cause of Coccidioidomycosis, also known as San Joaquin Valley Fever, an infectious fungal disease confined to the western hemisphere and endemic in American deserts. The host acquires the disease via respiratory inhalation of spores disseminated in their natural habitat.The causative agents of coccidioidomycosis are Coccidioides immitis and Coccidioides posadasii. Coccidioidomycosis is amazingly diverse in terms of its scope of clinical presentation, as well as clinical severity. 60% of infections as determined by serologic conversion are asymptomatic. The most common clinical syndrome in the other 40% of infected patients is an acute respiratory illness characterized by fever,cough, and pleuritic pain. Skin manifestations, such as erythema nodosum, are also common with Coccidioides infection. Coccidioides infection can cause a severe and difficult to-treat meningitis in AIDS patients, other immunocompromised patients, and occasionally immunocompetent hosts, and can occasionally cause acute respiratory distress syndrome and fatal multilobar pneumonia.The risk of symptomatic infection increases with age.
The most important endemic areas in the U. S. are found in Southern California and Southern Arizona, and in Mexico, in the states of Sonora, Nuevo León, Coahuila and Baja California where it resides in soil.
- Baptista-Rosas, Riquelme M, Hinojosa A. Ecological niche modeling of Coccidioides spp. in Western North American deserts. Ann N Y Acad Sci. 2007;1111:35-46.
2. Harrison's Principles of Medicine 17th edition