Tuberous Comfrey flowers from April to June, however it also reproduces asexually, that is vegetatively, having rhizomes that allow it to spread out from the original site, colonising and competing as it grows. This process continues into the autumn and the young clonal plants can be seen at this time of year, whilst the parent plants leaves are rotting down. Being very hardy, this plant is well able to survive northern winters.  Both the stems and leaves are softly hairy, the leaves have deep veining. 
The flowers themselves are a subtle pale creamy yellow, a significant characteristic for separating its identity from the purple flowered Russian Comfrey. The usual pollinators are the common carder bumble bee, honey bee, and red mason bee. The stem and leaves are clothed with soft hairs. The stem usually remains unbranched and the leaves are distinctly veined with a clear reduction in size from top to base.
S. tuberosum is naturally limited to the northern half of Great Britain, however it can be found throughout Europe. Distribution maps of the United Kingdom show the species to be common in Scotland and present, but uncommon, throughout much of England and Wales.
Vernacular common names such as 'Knitbone' reveal the homeopathic healing role that Tuberous Comfrey and the various hybrid comfreys have played in herbal medicine throughout the ages. In these traditional cures, the recipes make use of the leaves & roots, the former being used to speed up the healing of minor abrasions through their being applied directly to the damaged skin under a compress.
In spring the fresh young leaves may be used as an herb in cooked recipes, however due to their hairy nature and mildly toxic properties they are not eaten raw. As with Dandelion the root makes a palatable & non-acidic alternative to coffee once prepared, roasted until brown & brittle, and grind it into a powder.