Entamoeba hemolytica are generally considered to be anaerobic since they can be grown in vitro only under conditions of reduced oxygen tension. However, metabolically these parasitic protozoa have been found to be microaerobic or microaerophilic, consuming oxygen to a certain extent and produce toxic oxygen derivatives. Given this fact, it is notable that they lack some or all of the usual antioxidant defense mechanisms present in aerobic and other aerotolerant cells, a phenomenon reviewed and discussed by Tekwani and Mehlotra (1999).
- Tekwani, B.L. and R.K. Mehlotra. 1999. Molecular basis of defence against oxidative stress in Entamoeba histolytica and Giardia lamblia. Microbes and Infection. 1(5): 385-394.
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