Among the many genera of free-living amoebae that exist in nature, members of only four genera have a known association with human disease: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. Balamuthia mandrillaris are soil amoebae. In vitro, B. mandrillaris can feed on small amoebae (Acanthamoeba and Naegleria) and they may do so in nature. To date, B. mandrillaris is the only known species in the genus Balamuthia.
(Visvesvara et al. 2007)
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