Brachystemma calycinum is an indigenous plant of southwestern China and has shown promise as a natural adjunct anti-inflammatory agent for treatment of osteoarthritis in humans and dogs.[unreliable source?] This plant reported has active ingredients which result in decreased levels of protease activated receptor 2 (PAR 2), inducible nitric oxide synthase, and matrix metalloprotease 13.
- Maxim Moreau, Bertrand Lussier, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Christian Bédard, Dominique Gauvin & Eric Troncy (2012). "Brachystemma calycinum D. Don effectively reduces the locomotor disability in dogs with naturally occurring osteoarthritis: a randomized placebo-controlled trial". Evidence-based Complementary and Alternative Medicine 2012: 646191. doi:10.1155/2012/646191. PMC 3403515. PMID 22844335. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3403515/.
- Christelle Boileau, Johanne Martel-Pelletier, Judith Caron, Frédéric Paré, Eric Troncy, Maxim Moreau & Jean-Pierre Pelletier (2010). "Oral treatment with a Brachystemma calycinum D. Don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease-activated receptor 2". Annals of the Rheumatic Diseases 69 (6): 1179–1184. doi:10.1136/ard.2009.110965.
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