Predators of adults are most likely Accipitridae and Strigiformes. Nestlings and eggs are eaten by Piciformes, small Sciuridae, and climbing snakes, such as Opheodrys vernalis. White-breasted nuthatches respond to predators near their nest by pecking and flicking their wings while making "hn-hn" noises. They also use a piece of fur or vegetation to wipe around their nest opening when they leave the nest. This covers up their scent and keeps squirrels and other predators from using smell to find their nests.

Known Predators:

• hawks (Accipitridae)
• owls (Strigiformes)
• woodpeckers (Piciformes)
• squirrels (Sciuridae)
• climbing snakes (Serpentes)