Eastern spiny mouse has coarse, dark tan and spine-like fur on the upperparts of the body extended from behind the shoulder onto rump. Body color varies from pale-brown to brown in color on the upperparts especially mid-dorsum while the underparts and feet white. The ear is large with white patches. Whitish suborbital region. Tail long, slender, hairless except on closer inspection has short bristles, shorter than the head and body length, upper surface of the tail pale grayish brown and buff or white on the ventral surface. Palm and sole of the feet buff and without hairs. Claws whitish.
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