Cairo spiny mouse vary in size from small to medium. Fur spiny extending from behind the shoulder onto rump but not present on the side. Body color varies from pale to dark brownish cinnamon on the upperparts. Head dark. Underparts and feet white. Suborbital region small and white. Snout pointed. Ears large, erect, pigmented, with white basal and posterior patches and covered with whitish hairs. Eyes prominent and bright. Tail as long as the head and body length, hairless and scaly. Tail color grayish on the dorsal side and buff on the ventral side.
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