This native perennial plant is 2-4' tall and unbranched, except for some flowering side stems near the apex. The central stem and side stems are covered with long white hairs. The opposite leaves are up to 8" long and 2" across, and light or yellowish green. Their bases surround the central stem and merge together (perfoliate). In shape, they are lanceolate with long narrow tips and serrate margins. There is a conspicuous network of veins, particularly on the lower leaf surface. This lower surface is also pubescent. Some of the upper leaves near the inflorescence(s) are much smaller in size and sessile. The upper stems terminate in clusters of white flowerheads, spanning about 2-8" across. Each flowerhead is about 1/6" across and consists of about 15 disk florets. Each disk floret has 5 spreading lobes and a long divided style, in the manner of other Eupatorium spp. The blooming period is late summer to early fall, which typically lasts about 1-2 months for a colony of plants. There is a pleasant floral scent. The florets are replaced by achenes with small tufts of hair they are dispersed by the wind. The root system is fibrous and produces rhizomes in abundance. Common Boneset typically forms vegetative colonies.