The flowers are cross-pollinated by various insects, particularly small bees and various flies. Insects that eat the foliage of Spicebush include the caterpillars of Papilio troilus (Spicebush Swallowtail), Callosamia promethea (Promethea Moth), and Epimecis hortaria (Tulip Tree Beauty). The grubs of the long-horned beetle, Oberea ruficollis (Sassafras Borer), bore into the branches and roots of this shrub. The fruits are eaten occasionally by some upland gamebirds and several woodland songbirds (see the Bird Table for a listing of these species). These birds help to distribute the seeds to new locations.