The preference is full sun, mesic to dry conditions, and a sandy acid soil. This plant will flourish in other kinds of soil if the site is well-drained, including those that are rocky or contain clay. Sometimes the lower leaves will turn yellow, or the taproot will rot, if there is too much moisture in the ground. Also, if the taproot of a young plant is too close to the soil surface, it may not overwinter successfully due to heaving. Otherwise, Butterfly Milkweed is easy to grow, although somewhat slow to develop.