Eastern grey squirrels are important predators of seeds and other animals in the ecosystems in which they live. Their seed-caching activities may help disperse tree seeds. They may help to distribute truffle fungal spores when they eat truffles. Eastern grey squirrels are also prey animals themselves and are hosts for parasites such as ticks, fleas, lice, and roundworms. They are important and ubiquitous members of the forest ecosystems in which they live.

Eastern grey squirrels are important members of the forest ecosystems in which they live. They eat a lot of seeds. Their seed-caching activities may help disperse tree seeds. They may help to distribute truffle fungal spores when they eat truffles. They also prey on other animals in the ecosystem where they live. And of course eastern grey squirrels are also prey animals themselves! They are hosts for parasites such as ticks, fleas, lice, and roundworms.