Putative hybrids between Quercus bicolor and Q . macrocarpa are common in areas of contact. The hybrids tend to have more deeply lobed leaves and varying degrees of development of awns as a fringe along the margin of the acorn cup. Such characteristics occur sporadically throughout many populations of Q . bicolor ; in some cases they may occur because of subtle introgression.
The Iroquois used Quercus bicolor in the treatment of cholera, broken bones, consumption, and as a witchcraft medicine (D. E. Moerman 1986).