There are no major threats to this small anteater, although in some portions of its range it is hunted for meat, by domestic dogs, or sold as a pet species (Aguiar and Fonseca 2008; Noss et al. 2008; D.A. Meritt Jr. pers. comm. 2010). Habitat loss and degradation, wildfires, and road traffic represent a threat in some areas. In Uruguay, T. tetradactyla is affected by habitat loss due to the increase in eucalyptus plantations (A. Fallabrino pers. comm. 2010).