Gobiodon histrio is commercially harvested for the aquarium trade, however the harvest levels are not known. This species is also likely to be suffering localised population declines due to habitat degradation. Coral reefs in the Red Sea have been severely degraded by coral bleaching, Crown of Thorns starfish outbreaks, water pollution (sedimentation) and human population pressures. However these threats are not consistent over the entire range of this species.
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