This species is protected in Panama by national legislation (as Atelopus varius zeteki) decree No. 23 of January 30, 1967. It has been recorded from the protected areas of Parque Nacional Altos de Campana and Parque Nacional Omar Torrijos Herrera. A successful captive-breeding programme involving many zoos in North America is in place, although no re-introductions will be made until existing threats can be addressed. An ex-situ population of this species is held at the El Valle Amphibian Conservation Center in Panama; eggs and/or larvae have been produced to date (Edgardo Griffith pers. comm. September 2007).
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