In Alabama, commercial and personal take is limited to a daily bag limit of 10 turtles, and softshells can only be taken if over 12” CL. Florida closed its commercial fishery for the species in 2009. Take of the species in Georgia remains unregulated. In South Carolina Apalone ferox is considered a Species of Concern.
Substantial populations are protected in the Everglades and other protected areas; habitat characteristics also make some areas unsuitable to commercial fisheries, providing effective refugia. Habitat modification, particularly the construction of drainage canals, may favour individuals and populations locally.