Short-tailed cane mice live in a variety of habitats and therefore face a diverse group of predators. Major predators include various birds of prey, including barn owls, striped owl, white-tailed kites, and gray hawks; and small carnivorous mammals, including forest foxes and jaguarundi. Their coloration likely helps reduce risk of predation and the semi-fossorial tendencies help minimize interactions with potential predators.

Known Predators:

• barn owl (Tyto alba)
• striped owl (Asio clamator)
• white-tailed kites (Elanus leucurus)
• gray hawks (Asturina nitida)
• forest fox (Cerdocyon thous)
• jaguarundi (Felis jagouaroundi)