Zygodontomys brevicauda can be found in a wide variety of habitats including grasslands, marshes, roadsides, forests and agricultural lands, and is typically found at lower elevations (0 to 600 m). Because it can inhabit many different environments, it is better-suited than most sigmodontinids for inhabiting areas near human development, including areas dominated by invasive plant species. Zygodontomys brevicauda is most commonly found in open fields with dense grass or ground cover, where it creates runways connecting feeding and nesting areas.
Range elevation: 0 to 600 m.
Habitat Regions: tropical ; terrestrial
Terrestrial Biomes: savanna or grassland ; forest ; rainforest
Other Habitat Features: agricultural