There are no records on how many clymene dolphins have been captured or killed, but clymene dolphins are occasionally taken by harpoon in small numbers in the Lesser Antilles (Caribbean) small cetacean fishery. They are captured in gillnets in Venezuelan waters, where they are used for longline shark bait and human consumption. They may also betaken in tuna purse seines in the eastern tropical Atlantic.

Contaminant levels have not been recorded.

US Federal List: no special status

CITES: appendix ii

IUCN Red List of Threatened Species: data deficient