Peromyscus maniculatus is an abundant species, often among the most abundant mouse species of certain areas (LTER 1998). Densities can reach 11 mice per acre (Baker 1983). Quantity and quality of foods, availability of water, number and distribution of nest sites, architecture of living and dead vegetation, and depth and density of litter are some ecological factors proposed to affect the density of P. maniculatus. However, only the availability of food has been studied in enough detail to show it has an effect on population density (Kirkland and Layne 1989).
US Federal List: no special status
CITES: no special status
State of Michigan List: no special status
IUCN Red List of Threatened Species: least concern