Peromyscus gossypinus is not considered endangered by any organizations. However, there are several subspecies of P. gossypinus, two of which are considered to have attained a conservation status with various organizations.
Peromyscus gossypinus allapaticola, the Key Largo cotton mouse, has received the Vulnerable D2 status with the IUCN, which means that the population is restricted to an acutely small area of occupancy, in which any disturbance could result in the endangerment or extinction of the subspecies. It is also considered endangered by the U.S. Fish and Wildlife Service.
Peromyscus gossypinus restrictus, the Chadwick Beach cotton mouse, is extinct, according to the IUCN. This subspecies was native to Florida.
US Federal List: endangered; no special status
CITES: no special status
IUCN Red List of Threatened Species: least concern