Peromyscus gossypinus can be found in a variety of habitats, ranging from swamplands to much drier sand dunes. Generally, these mice reside on the forest floor, using hollowed logs, vines, and brushes as shelter. One study concluded that the primary habitiat of cotton mice is underground tortoise burrows, presumably for the stable microclimate they provide.
This species is common in wooded areas along the edges of streams and in areas of potential flooding. However, this species can also be found in areas of less dense vegetation, such as fields cleared by humans, old buildings, and the previously mentioned sand dunes.
Habitat Regions: temperate ; terrestrial
Terrestrial Biomes: desert or dune ; savanna or grassland ; forest ; scrub forest
Other Habitat Features: suburban ; riparian