This is the largest of the American tree frogs. Males generally have a maximum size of 5.1-6.3 cm (SVL), with females being much larger, attaining a size of 12.7 cm (SVL). Osteopilus septentrionalis is highly variable in color, but they are usually some shade of gray, tan or olive, occasionally with dark, marbled blotches dorsally. Their skin is very textured, and they have extremely large eyes and toe pads (Bartlett, 1996).
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