Commensal populations of Mus musculus are generally stable and densities can be as high as 10 mice per square meter. In the wild, populations are less stable and densities may be less than 1 mouse per 100 square meters. Overall, populations are flourishing and are in fact aided by human construction of houses, barns, and other structures.

US Federal List: no special status

CITES: no special status

State of Michigan List: no special status

IUCN Red List of Threatened Species: least concern