According to the IUCN Red List of Threatened Species Monodelphis kunsi is an endangered species due to a decline in area of occupancy, extent of occurrence and/or quality of habitat. Vargas, Tarifa and Cortez (2003) reported that numbers of M. kunsi are declining due to human induced habitat degradation. They estimated that populations declined as much as 50% in the last decade.
US Federal List: no special status
CITES: no special status
IUCN Red List of Threatened Species: least concern