In the central Chaco regions intensive hunting has resulted in a local decline. In Venezuela habitat destruction and illegal hunting may pose a threat, especially around settled areas.
In the Tamshiyacu-Tahuayo Community Reserve of the Peruvian Amazon the gray brocket is one of the focal species in a community based wildlife management initiative.
US Federal List: no special status
CITES: no special status
IUCN Red List of Threatened Species: least concern