Mottled sculpin have been reported as prey by brook trout, brown trout, northern pike, common mergansers, and water snakes. They are also likely prey of wading birds, such as herons.
- brook trout (Salvelinus fontinalis)
- brown trout (Salmo trutta)
- northern pike (Esox lucius)
- common mergansers (Mergus merganser)
- water snakes (Nerodia sipedon)
- herons (Ardeidae)
Anti-predator Adaptations: cryptic