According to the IUCN Red List, the status of Choloepus hoffmanni is of least concern due to their large distribution, large population sizes, and ability to inhabit somewhat disturbed areas.
Several factors that serve as potential population limiting factors of Choloepus hoffmanni include deforestation, agricultural activity, illegal trafficking, and an increase in human settlements. In addition, local communities bordering the habitats of Choloepus hoffmanni have been known to take these sloths up as pets. In efforts to combat the negative consequences due to human impingement several rescue and rehabilitation centers have been built to assist those animals that are injured. Although there are obvious negative consequences of habitat removal for animals as a whole, it has been hypothesized that C. hoffmanni might benefit from forest fragmentation which create edge habitats.
US Federal List: no special status
CITES: appendix iii
State of Michigan List: no special status
IUCN Red List of Threatened Species: least concern