Mexican red-knee tarantulas reside in dry areas with little vegetation, usually in scrubland, deserts, dry thorn forests, or tropical deciduous forests. They live in burrows in rocky areas at the base of thorny vegetation like cacti. Burrows usually have one entrance that is a little wider than the tarantula itself. A web carpet extends from the burrow out of the opening but is usually covered or coated in the substrate of the area. When the burrow is in use, silk can be found near the entrance. During the reproductive season, extra silk is present in the burrows of mature females.

Habitat Regions: tropical ; terrestrial

Terrestrial Biomes: rainforest ; scrub forest