The cells of Mycobacterium tuberculosis detect, move, and sequester toxic copper via membrane copper pumps and protein chaperones.
"Copper is an essential micronutrient that is involved in protein-mediated electron transfer and enzyme activity, yet reduced copper in its +1 oxidation state is highly toxic to cells. As a result, cellular regulation of copper is highly controlled, involving cell-surface copper pumps and protein chaperones that move copper around the cell, delivering it to specific target proteins and concurrently sequestering it to protect the cell from toxicity." (Wilmot 2007:15)
Learn more about this functional adaptation.
- Wilmot, Carrie M. 2007. Fighting toxic copper in a bacterial pathogen. Nat Chem Biol. 3(1): 15-16.
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